The drugs are also available in several combinations with other over-the-counter cough and cold medications. These drugs are both nasal decongestants. The chart below is a quick snapshot of some of the basic information for pseudoephedrine and phenylephrine. However, the illegal methamphetamine that it can be used to make is highly addictive. You can walk into any pharmacy and buy phenylephrine off the shelf like you would for any other purchase.
But for pseudoephedrine, there are special requirements. To get it, you have to buy it from the pharmacy staff, not off the shelf.
The reason for these requirements is that pseudoephedrine is used to make illegal methamphetamine, which is highly addictive. These rules help prevent people from buying products that contain pseudoephedrine to make methamphetamine.
Studies in and found pseudoephedrine to be more effective than phenylephrine in the treatment of nasal congestion. Both pseudoephedrine and phenylephrine can cause side effects. Call your doctor if you have any serious side effects when using these drugs. Rebound congestion congestion that occurs from overuse of nasal decongestants may also develop if nasal phenylephrine is used more times in one day or for more days than indicated on the label.
An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. This can help your doctor prevent possible interactions. One class of drugs that is known to interact with both pseudoephedrine and phenylephrine is monoamine oxidase inhibitors MAOIs.
This class includes drugs such as:. Ask your doctor about other treatment options. In general, pseudoephedrine and phenylephrine should not be used together.
Combining them could lead to increases in both blood pressure and heart rate. Jerry -- thanks for the reply - so in that case Sudafed is the same as the decongestant used in Claritin-D.
Is that correct? I am trying to decide what allergy med to switch too now that Claritin is no longer covered by my insurance plan. Thanks Bob. Do you want an antihistamine or a decongestant? They are not the same thing. Have had very good results with Claritin-D so am leary to try something new.
However - with Claritin no longer being covered my my HMO, I was looking for what other product might come close. Turns out that the only other med covered is Allegra, which I tried once and did not have good result with. Yes, there is only one decongestant, pseudoephedrine, approved in the US there used to be two, and the other, PPA, was banned a couple years ago.
Any medicine, prescription or OTC, that contains decongestant, contains pseudoephedrine including all the -D antihistamines.
Email via: pharmchemshop AT gmail. You should consult a pharmacist or other healthcare professional for a complete list. Source: DailyMed phenylephrine DailyMed pseudoephedrine. Phenylephrine and pseudoephedrine have a very similar drug interaction profile due to their adrenergic effects on the alpha and beta receptors.
Alpha-blockers, such as tamsulosin, may diminish the vasoconstrictive properties of both decongestants making them less effective. MAO inhibitors, such as selegiline, and ergot derivatives, such as bromocriptine, may enhance the hypertensive effects of the decongestants.
This would be concerning in someone with pre-existing hypertension who may be considering decongestant use. The combination of phenylephrine or pseudoephedrine with either MAO inhibitors or ergot derivatives is contraindicated.
The following list is not meant to be a complete list of all potential drug interactions. Please consult your pharmacist or physician for a complete list and more information. Phenylephrine and pseudoephedrine are available without a prescription and are generally considered to be safe drugs. Due to their effects on the cardiac system, patients with high blood pressure and heart disease should not use these drugs without explicit consent from their physician.
These drugs are intended for short-term use for the relief of acute rhinitis and sinus pressure. Patients who experience these symptoms for longer than seven days, or who develop a fever, should consult a physician. Phenylephrine is in pregnancy category C which means that studies in animals showed adverse effects to the fetus. When a drug is category C, there may be some situations where the benefit to the pregnant patient outweighs the risk, and phenylephrine should not be used without consent from your physician.
Pseudoephedrine is pregnancy category B which means that animal studies have not shown adverse effects to the fetus. Pseudoephedrine is considered safe to take when pregnant after consulting your physician. Pseudoephedrine should, however, be avoided in the first trimester.
Phenylephrine is an over-the-counter nasal decongestant available in 5 mg and 10 mg tablets, as well as an oral solution. It is also available in an injectable form which is only used in an inpatient setting by medical professionals for low blood pressure.
Pseudoephedrine is an over-the-counter nasal decongestant available in 30 mg and 60 mg tablets, as well as mg and mg extended-release tablets. It is also available as an oral solution. Pseudoephedrine purchases must be done at a pharmacy and the purchase information must be logged into a database. Purchase limits are set by state and federal guidelines. Phenylephrine and pseudoephedrine are both adrenergic agonists. Phenylephrine has primarily an affinity to only alpha-adrenergic receptors, while pseudoephedrine has an affinity to both alpha- and beta-adrenergic receptors.
Their side effect profiles are very similar. Studies have shown that pseudoephedrine is a much more effective decongestant than phenylephrine. The effects of both drugs may be augmented with concurrent use of other products that affect rhinitis, such as antihistamines. Phenylephrine should not be used when pregnant unless the benefit to the mother outweighs the risk. Pseudoephedrine is considered safe to take after the first trimester.
Always consult your physician before taking a nasal decongestant when pregnant. Phenylephrine does stimulate alpha-adrenergic receptors which may make it responsible for central nervous system stimulant effects such as restlessness, anxiety, and insomnia.
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